ABSTRACT
OBJECTIVE:To study the effects of nimesulide combined with oxaliplatin on microvessel density and immune func-tion of esophageal cancer model rats. METHODS:48 rats were selected to establish esophageal cancer model and then randomly di-vided into model group,oxaliplatin group,nimesulide group and combination group,with 12 rats in each group. 1 d after model-ing,model group was given 5% Glucose injection 1 mL via tail vein,3 times a week,and constant volume of Sodium carboxy-methylcellulose solution,once a week. Oxaliplatin group was given oxaliplatin 13.6 mg/kg via tail vein,3 times a week. Nimesu-lide group was given nimesulide 20 mg/kg intragastrically,once a week. Combination group was given oxaliplatin and nimesulide with same usage as above. The administration lasted for 8 weeks. The cancer growth,microvessel density of cancer tissue,peripher-al blood immune function index were observed in four groups. RESULTS:Compared with model group,cancer size,cancer weight,integral absorbance of cancer and positive vessel density were all decreased in treatment groups(P<0.05). The number of peripheral blood CD3+,CD4+T cells and CD4+/CD8+were all decreased in oxaliplatin group and combination group,while the num-ber of CD8+T cells was decreased(P<0.05). Compared with nimesulide group,cancer size,cancer weight,integral absorbance of cancer,positive vessel density,the number of peripheral blood CD3+,CD4+T cells and CD4+/CD8+ were all decreased in oxaliplat-in group and combination group,while tumor inhibition rate and the number of CD8+T cells were all increased(P<0.05);combi-nation group was more significant than oxaliplatin group (P<0.05). CONCLUSIONS:Oxaliplatin combined with nimesulide can effectively inhibit cancer growth of esophageal cancer,the mechanism of which may be associated with inhibiting angiogenesis of tumor tissue and strengthening immune function.